RESUMO
Introducción y objetivo: Nuestro objetivo es analizar la incidencia de tuberculosis (TB) en nuestra población y comparar las características de los pacientes con y sin infección por VIH (I-VIH). Pacientes y métodos: Estudio clínico-epidemiológico de cohortes retrospectivo. Se incluyeron pacientes diagnosticados de TB con y sin I-VIH entre los años 2005-2016 en la provincia de Guadalajara (España). Se analizaron variables epidemiológicas, clínicas, microbiológicas y terapéuticas, incluyendo las resistencias microbiológicas. Resultados: Se realizaron 261 diagnósticos de TB. Hubo 25 pacientes (9,6%) que presentaban I-VIH, los cuales eran predominantemente varones, tenían una mayor incidencia de virus de la hepatitis C, mayor porcentaje de afectación extrapulmonar, una mayor prevalencia de resistencia a la isoniacida y a la rifampicina así como una mayor respuesta paradójica y estancia media más prolongada. Por otra parte, presentaron menor porcentaje de prueba de tuberculina positiva y de baciloscopias en esputo positivas. Un porcentaje significativo de pacientes con TB no tenían realizada una serología para VIH. Conclusión: Los pacientes con I-VIH muestran notables diferencias en variables epidemiológicas, clínicas y de resistencia a los fármacos antituberculosos. En un porcentaje elevado de pacientes con TB se desconoce su serología para VIH
Background and objective: Our objective is to analyze the incidence of tuberculosis (TB) in our population and to compare the characteristics of patients with and without HIV infection. Patients and methods: Clinical-epidemiological retrospective cohort study that included patients diagnosed with TB with and without HIV infection between 2005-2016 in the province of Guadalajara (Spain). Epidemiological, clinical, microbiological and therapeutic variables were assessed, including microbiological resistances. Results: TB was diagnosed in 261 patients. There were 25 patients (9.6%) who had HIV infection. Patients with HIV infection were predominantly males, had higher incidence of hepatitis C virus, a higher percentage of extrapulmonary TB, a higher prevalence of resistance to isoniazid and rifampicin, a greater paradoxical response and a longer average hospital stay. On the other hand, they had a lower percentage of positive tuberculin skin test and positive sputum smear (microscopy). A significant percentage of TB patients had no serology for HIV. Conclusion: Patients with HIV infection show remarkable differences in epidemiological, clinical and resistance variables to antituberculosis drugs. A high percentage of patients with TB were not tested for HIV
Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Tuberculose/epidemiologia , Tuberculose/microbiologia , Infecções por HIV/complicações , Tuberculose/tratamento farmacológico , Estudos de Coortes , Estudos Retrospectivos , Espanha/epidemiologia , Antituberculosos , Tuberculose Resistente a Múltiplos MedicamentosRESUMO
BACKGROUND AND OBJECTIVE: Our objective is to analyze the incidence of tuberculosis (TB) in our population and to compare the characteristics of patients with and without HIV infection. PATIENTS AND METHODS: Clinical-epidemiological retrospective cohort study that included patients diagnosed with TB with and without HIV infection between 2005-2016 in the province of Guadalajara (Spain). Epidemiological, clinical, microbiological and therapeutic variables were assessed, including microbiological resistances. RESULTS: TB was diagnosed in 261 patients. There were 25 patients (9.6%) who had HIV infection. Patients with HIV infection were predominantly males, had higher incidence of hepatitis C virus, a higher percentage of extrapulmonary TB, a higher prevalence of resistance to isoniazid and rifampicin, a greater paradoxical response and a longer average hospital stay. On the other hand, they had a lower percentage of positive tuberculin skin test and positive sputum smear (microscopy). A significant percentage of TB patients had no serology for HIV. CONCLUSION: Patients with HIV infection show remarkable differences in epidemiological, clinical and resistance variables to antituberculosis drugs. A high percentage of patients with TB were not tested for HIV.
Assuntos
Tuberculose/epidemiologia , Adulto , Estudos de Coortes , Feminino , Infecções por HIV/complicações , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Tuberculose/complicações , Tuberculose/diagnóstico , Tuberculose/tratamento farmacológicoRESUMO
No disponible
Assuntos
Masculino , Lactente , Humanos , Linfadenite/microbiologia , Mycobacterium/patogenicidade , Infecções por Mycobacterium/microbiologia , Doenças Transmissíveis Emergentes/microbiologiaAssuntos
Ceratite por Acanthamoeba/etiologia , Acanthamoeba/isolamento & purificação , Soluções para Lentes de Contato/efeitos adversos , Lentes de Contato Hidrofílicas/efeitos adversos , Ceratite por Acanthamoeba/diagnóstico , Ceratite por Acanthamoeba/tratamento farmacológico , Adolescente , Animais , Opacidade da Córnea/etiologia , Contaminação de Medicamentos , Contaminação de Equipamentos , Fungos/isolamento & purificação , Bactérias Gram-Negativas/isolamento & purificação , Humanos , MasculinoRESUMO
No disponible
